DMPI Endocrinology

2019

52.

2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

​

John B Buse, Deborah J Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A D'Alessio, Melanie J Davies

​

Diabetes Care

51.

2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

​

John B Buse, Deborah J Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A D'Alessio, Melanie J Davies

​

Diabetologia

50.

Pharmacological Antagonism of the Incretin System Protects Against Diet-induced Obesity. 

​

Berit Svendsen, Megan E Capozzi, Jingjing Nui, Sarah A Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A D’Alessio, Jonathan E Campbell. 

​

Molecular Metabolism

49.

Rapid hepatic metabolism blunts the endocrine actions of portally infused GLP-1 in male rats.

​

Benedikt A Aulinger, Marta Perabo, Randy J Seeley, Klaus G Parhofer, David A D'Alessio

​

American Journal of Physiology Endocrinology and Metabolism

48.

The effects of preioperative dexamethasone on glycemic control and postoperative outcomes.

​

Rebecca A Herbst, Onala T Telford, John Hunting, W Michael Bullock, Erin Manning, Beatrics D Hong, David A D'Alessio, Tracy L Setji

​

Endocrine Practice

47.

L-citrulline supplementation improvew glucose and exercise tolerance in obese male mice 

​

Amina Eshreif, Rami Al Batran, K Lockhart Jamieson, Ahmed M Darwesh, Keshav Gopal, Amanda A Greenwell, Igor Zlobine, Hanin Aburasayn, Farah Eaton, Erin E Mulvihill, Jonathan E Campbell, John M Seubert, John R Ussher

​

Experimental Physiology

46.

The role of GIP in α-cells and glucagon secretion

​

Kimberley El, Jonathan E Campbell

​

Peptides

45.

Physiological roles of the GIP receptor in murine brown adipose tissue

​

Jacqueline L Beaudry, Kiran D Kaur, Elodie M Varin, Laurie L Baggio, Xiemin Cao, Erin E Mulvihill, Holly E Bates, Jonathan E Campbell, Daniel J Drucker

​

Molecular Metabolism

44.

The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control

​

Jonathan D Douros, Jenny Tony, David A D'Alessio

​

Endocrine Reviews

43.

Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control

​

Jonathan D Douros, Jingjing Niu, Sophia Sdao, Trillian Gregg, Matthew J Merrins, Jonathan Campbell, Jenny Tong, David D'Alessio

​

Molecular Metabolism

42.

The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice.

​

Chelsea R. Hutch, Karen Roelofs, April Haller, Joyce Sorrell, Kyle Leix, David A. D'Alessio, Robert Augustin, Randy J. Seeley, Thomas Klein, Darleen A. Sandoval

​

Diabetologia

41.

Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery

​

Marzieh Salehi, Amalia Gastaldelli, David A D'Alessio

​

Gut

40.

One small step for mice, one giant leap for GWAS?

​

Mark A Herman, Jonathan E Campbell, David A D’Alessio

​

Journal of Clinical Investigation

39.

Glucagon lowers glycemia when β cells are active

​

Megan E Capozzi, Jacob B Wait, Andrew N Gordon Jepchumba Koech, Reilly W Coch, Berit Svendsen, Brian Finan, David A D’Alessio, Jonathan E Campbell

​

JCI Insight

38.

Intra-Islet Ghrelin Signaling does not Regulate Insulin Secretion from Adult Mice

​

Sarah M Gray, Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E Campbell, David A D’Alessio, Jenny Tong

​

Diabetes

37.

Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes

​

Brian Finan, Megan E Capozzi, Jonathan E Campbell

​

Diabetes

36.

Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycemia

​

Marzieh Salehi, Amalia Gastaldelli, David A D'Alessio

​

Diabetes, Obesity, and Metabolism

35.

Reg3 Proteins as Gut Hormones? Don’t Be Hasty

​

Jonathan D Douros, Jonathan E Campbell

​

Endocrinology

34.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

​

Jacqueline L Beaudry, Kiran Deep Kaur, Elodie M Varin, Laurie L Baggio, Xiemin Cao, Erin E Mulvihill, Jennifer H Stern, Jonathan E Campbell, Phillip E Scherer, Daniel J Drucker

​

Molecular Metabolism

33.

Sleeve gastrectomy rapidly enhances islet function independently of body weight

​

Jonathan D Douros, Jingjing Niu, Sophia Sdao, Trillian Gregg, Kelsey Fisher-Wellman, Manish Bharadwaj, Anthony Molina, Ramamani Arumugam, MacKenzie Martin, Enrico Petretto, Matthew J Merrins, Mark A Herman, Jenny Tong, Jonathan E Campbell, David A D’Alessio

​

JCI Insight

32.

Beta Cell tone is defined by proglucagon peptides through cAMP signaling

​

Megan E Capozzi, Berit Svendsen, Sara E Encisco, Sophie L Lewandowski, Mackenzie D Martin, Haopeng Lin, Justin L Jaffe, Reilly W Coch, Jonathan M Haldeman, Patrick E MacDonald, Matthew J Merrins, David A D’Alessio, Jonathan E Campbell

​

JCI Insight

31.

Circulating levels of soluble dipeptidyl peptidase-4 are dissociated from inflammation and induced by enzymatic dpp4 inhibition

​

Elodie M Varin, Erin E Mulvihill, Jacqueline L Beaudry, Gemma Pujadas, Shai Fuchs, Jean-François Tanti, Sofia Fazio, Kirandeep Kaur, Xiemin Cao, Laurie L Baggio, Dianne Matthews, Jonathan E Campbell, Daniel J Drucker

​

Cell Metabolism

2018

30.

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

​

Melanie J Davies, David A D'Alessio, Judith Fradkin, Walter N Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J Wexler, John B Buse

​

Diabetologia

29.

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

​

Melanie J Davies, David A D'Alessio, Judith Fradkin, Walter N Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J Wexler, John B Buse

​

Diabetes

28.

Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet

​

Rami Al Batran, Keshav Gopal, Mackenzie D Martin, Kim L Ho, Malak Almutairi, Hanin Aburasayn, Farah Eaton, Jonathan E Campbell, John R Ussher

​

Diabetologia

27.

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

​

Tamer Coskun, Kyle W Sloop, Corina Loghin, Jorge Alsina-Fernandex, Shweta Urva, Krister B Bokvist, Xuewei Cui, Daniel A Briere, Over Cabrera, William C Roell, Uma Juchibholta, Julie S Moyers, Charles T Benson, Ruth E Gimeno, David A D'Alessio, Axel Haupt

​

Molecular Metabolism

26.

Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans

​

Laura C Page, Amalia Gastaldelli, Sarah M Gray, David A D'Alessio, Jenny Tong

​

Diabetes

25.

Enhanced glucose control following vertical sleeve gastrectomy does not require a β-cell glucagon-like peptide 1 receptor

​

Jonathan D Douros, Alfor G Lewis, Eric P Smith, JingJing Niu, Megan Capozzi, April Wittmann, Jonathan Campbell, Jenny Tong, Constance Wagner, Parinaz Mahbod, Randy Seeley, David A D’Alessio

​

Diabetes

24.

Can we RISE to the Challenge of Youth-Onset Type 2 Diabetes?

​

John B Buse, David A D'Alessio, Matthew C Riddell

​

Diabetes Care

23.

Remodeling of the acetylproteome by SIRT3 manipulation fails to affect insulin secretion or β cell metabolism in the absence of overnutrition

​

Brett S Peterson, Jonathan E Campbell, Olga Ilkayeva, Paul A Grimsrud, Matthew D Hirschey, Christopher B Newgard

​

Cell Reports

22.

Targeting the incretin/glucagon system with triagonists to treat diabetes

​

Megan E Capozzi, Richard D DiMarchi, Matthias H Tschöp, Brian Finan, Jonathan E Campbell

​

Endocrine Reviews

21.

Inactivation of the glucose-dependent insulinotropic polypeptide receptor improves outcomes following experimental myocardial infarction

​

John R Ussher, Jonathan E Campbell, Erin E Mulvihill, Laurie L Baggio, Holly E Bates, Brent A McLean, Keshav Gopal, Megan Capozzi, Bernardo Yusta, Xiemin Cao, Safina Ali, Minsuk Kim, M Golam Kabir, Yutaka Seino, Jinya Suzuki, Daniel J Drucker

​

Cell Metabolism

2017

20.

Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes

​

Matthew J Crowley, John W Williams, Andrzej S Kosinski, David A D'Alessio, John B Buse

​

Diabetes Care

19.

β-cell inactivation of GPR119 unmasks incretin dependence of GPR119-mediated glucoregulation

​

Brandon L Panaro, Grace B Flock, Jonathan E Campbell, Jacqueline L Beaudry, Xiemin Cao, Daniel J Drucker

​

Diabetes

18.

SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion

​

Kristin A Anderson, Frank K Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S Peterson, Jonathan D Douros, Gregory R Wagner, J Will Thompson, Andreas S Madsen, Michelle F Green, R Michael Sivley, Olga R Ilkayeva, Robert D Stevens, Donald S Backos, John A Capra, Christian A Olsen, Jonathan E Campbell, Deborah M Muoio, Paul A Grimsrud, Matthew D Hirschey

​

Cell Metabolism

17.

DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain

​

Jonathan E Campbell, David A D’Alessio

​

Journal of Clinical Investigation

16.

Disruption of Glucagon-LIke Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress

​

Sriparna Ghosal, Amy EB Packard, Parinaz Mahbod, Jessica M McKlveen, Randy J Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P Smith, David A D'Alessio, James P Herman

​

Journal of Neuroscience

15.

Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis

​

Erin E Mulvihill, Elodie M Varin, Bojana Gladanac, Jonathan E Campbell, John R Ussher, Laurie L Baggio, Bernardo Yusta, Jennifer Ayala, Melissa A Burmeister, Dianne Matthews, KW Annie Bang, Julio E Ayala, Daniel J Drucker

​

Cell Metabolism

2016

14.

Incretin-based therapies for the failing heart

​

John R Ussher, Jonathan E Campbell

​

Cardiovascular Endocrinology & Metabolism

13.

Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor - Maybe

​

Marzieh Salehi, David A D'Alessio

​

Surgery for Obesity and Related Disease

12.

Inhibition of dipeptidyl peptidase-4 impairs ventricular function and promotes cardiac fibrosis in high fat–fed diabetic mice

​

Erin E Mulvihill, Elodie M Varin, John R Ussher, Jonathan E Campbell, KW Annie Bang, Tahmid Abdullah, Laurie L Baggio, Daniel J Drucker

​

Diabetes

11.

Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care

​

Bruce M Wolfe, David A D'Alessio

​

Obesity

10.

TCF1 links GIPR signaling to the control of beta cell function and survival

​

Jonathan E Campbell, John R Ussher, Erin E Mulvihill, Jelena Kolic, Laurie L Baggio, Xiemen Cao, Yu Liu, Benjamin J Lamont, Tsukasa Morii, Catherine J Streutker, Natalia Tamarina, Louis H Philipson, Jeffrey L Wrana, Patrick E MacDonald, Daniel J Drucker

​

Nature Medicine

9.

The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?

​

Benedikt A Aulinger, Torsten P Vahl, Ron L Prigeon, David A D'Alessio, Deborah A Elder

​

American Journal of Physiology Endocrinology and Metabolism

2015

8.

Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus

​

Roger D Gibb, Johnson W McRorie, Darrel A Russell, Vic Hasselblad, David A D'Alessio

​

Amercial Journal of Clincial Nutrition

7.

Insulin Sensitivity and Beta-cell Function Improve after Gastric Bypass in Severely Obese Adolescents

​

Thomas H Inge, Ronald L Prigeon, Deborah A Elder, Todd M Jenkins, Robert M Cohen, Stavra A Xanthakos, Stephen C Benoit, Lawrence M Dolan, Stephen R Daniels, David A D'Alessio

​

Journal of Pediatrics

6.

Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone

​

Daniel Oropeza, Nathalie Jouvet, Lionel Budry, Jonathan E Campbell, Khalil Bouyakdan, Julie Lacombe, Gabrielle Perron, Valerie Bergeron, Joshua C Neuman, Harpreet K Brar, Rachel J Fenske, Clemence Meunier, Sarah Sczelecki, Michelle E Kimple, Daniel J Drucker, Robert A Screaton, Vincent Poitout, Mathieu Ferron, Thierry Alquier, Jennifer L Estall

​

Diabetes

5.

Islet α cells and glucagon—critical regulators of energy homeostasis

​

Jonathan E Campbell, Daniel J Drucker

​

Nature Reviews Endocrinology

4.

Insulin Determir is Transported From Blood to Celebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

​

Denovan P Begg, Aaron A May, Joram D Mul, Min Liu, David A D'Alessio, Randy J Seeley, Stephen C Woods

​

Diabetes

3.

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

​

Jacqueline A Koehler, Laurie L Baggio, Xiemin Cao, Tahmid Abdulla, Jonathan E Campbell, Thomas Secher, Jacob Jelsing, Brett Larsen, Daniel J Drucker

​

Diabetes

2.

Diet-induced obese mice retain endogenous leptin action

​

Nickki Ottaway, Parinaz Mahbod, Belen Rivero, Lee Ann Norman, Arieh Gertler, David A D'Alessio, Diego Perez-Tilve

​

Cell Metabolism

1.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

​

Brian Finan, Bin Yang, Nickki Ottaway, David L Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, Lianshan Zhang, Kirk M Habegger, Katrin Fischer, Jonathan E Campbell, Darleen Sandoval, Randy J Seeley, Konrad Bleicher, Sabine Uhles, William Riboulet, Jürgen Funk, Cornelia Hertel, Sara Belli, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Daniel J Drucker, Vasily Gelfanov, Paul T Pfluger, Timo D Müller, Diego Perez-Tilve, Richard D DiMarchi, Matthias H Tschöp

​

Nature Medicine

69.

Mechanisms controlling pancreatic islet cell function in insulin secretion

​

Jonathan E. Campbell, Christopher B. Newgard

​

Nature Reviews Molecular Cell Biology

2020

68.

Revisiting the complexity of GLP-1 action - from sites of synthesis to receptor activation

​

Brent A. McLean, Chi Kin Wong, Jonathan E. Campbell, David J. Hodson, Stefan Trapp, Daniel J. Drucker

​

Endocrine Reviews

67.

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

​

Guo-Fang Zhang, Mette V. Jensen, Sarah M. Gray, Kimberley El, You Wang, Danhong Lu, Thomas C. Becker, Jonathan E. Campbell, Christopher B. Newgard

​

Cell Metabolism

66.

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms

​

 Jonathan E. Campbell

​

Molecular Metabolism

65.

Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway

​

Sophie L. Lewandowski, Rebecca L. Cardone, Hannah R. Foster, Thuong Ho, Evgeniy Potapenko, Chetan Poudel, Halena R. VanDeusen, Sophia M. Sdao, Tiago C. Alves, Xiaojian Zhao, Megan E. Capozzi, Arnaldo H. de Souza, Ishrat Jahan, Craig J. Thomas, Craig S. Nunemaker, Dawn B. Davis, Jonathan E. Campbell, Richard G. Kibbey, Matthew J. Merrins

​

Cell Metabolism

64.

Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes

​

Kimberly M. Alonge, David A D'Alessio, Michael W. Schwartz

​

Diabetologia

63.

Repositioning the alpha cell in postprandial metabolism

​

Kimberley El, Megan E. Capozzi, Jonathan E. Campbell

​

Endocrinology

62.

Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice

​

Frank K. Huynh, Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M.S. Llaguno, Thi-Tina N. Nguyen, Jonathan E. Campbell, Samuel B. Stephens, Christopher B. Newgard, Matthew D. Hirschey

​

American Journal of Physiology: Endocrinology and Metabolism

61.

Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia

​

Caslin A. Gilroy, Megan E. Capozzi, Anastasia K. Varanko, Jenny Tong, David A. D'Alessio, Jonathan E. Campbell, Ashutosh Chilkoti

​

Science Advances

60.

Could micro changes in beta-cells enable major changes in metabolism?

​

Megan E. Capozzi,  Jonathan E. Campbell

​

EBioMedicine

59.

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

​

Francis S. Willard, Jonathan D. Douros, Maria B.N. Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J.C. van der Velden, Cynthia Stutsman, Guemalli R. Cardona, Shweta Urva, Paul J. Emmerson, Jens J. Holst, David A. D'Alessio, Matthew P. Coghlan, Mette M. Rosenkilde, Jonathan E. Campbell, Kyle W. Sloop

​

JCI Insight

58.

Preliminary evidence of effects of potassium chloride on a metabolic path to diabetes and cardiovascular disease

​

Ranee Chatterjee, Clementine A. Davenport, Lydia Kwee, David D'Alessio, Laura P. Svetkey, Pao-Hwa Lin, Cris A. Slentz, Olga Ilkayeva, Johanna Johnson, David Edelman, Svati H Shah

​

Metabolomics

57.

Thermic effect of food and resting energy expenditure after sleeve gastrectomy for weight loss in adolescent females

​

Bonnie Brehm, Suzanne Summer, Todd Jenkins, David D'Alessio, Thomas Inge

​

Surgery for Obesity and Related Disorders

56.

Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study

​

Jeremy H. Pettus, David A D'Alessio, Juan P. Frias, Eric G. Vajda, James D. Pipkin, Julio Rosenstock, Gretchen Williamson, Miriam A. Zangmeister, Lin Zhi, Keith B. Marschke

​

Diabetes Care

55.

Discordance between GLP-1R gene and protein expression in mouse pancreatic islets cells

​

Sarah M. Gray, Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, Peter Ravn, Kyle W. Sloop, Jenny Tong, Jesper Gromada, Jonathan E. Campbell, David A. D'Alessio

​

Journal of Biological Chemistry

54.

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

​

Rami Al Batran, Keshav Goal, Megan E. Capozzi,  Jadin J. Chahade, Bruno Saleme, S. Amirhossein Tabatabaei-Dakhili, Amada A. Greenwell, Jingjing Nui, Malak Almutairi, Nikole J. Myme, Grant Masson, Ryekjang Kim, Carlos A. Velazquez-Martinez, Celine Agues, Peter A. Crawford, Gopinath Sutendra, Jonathan E. Campbell, Jason R.B. Dyck, John R. Ussher. 

​

Cell Metabolism

53.

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

​

Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, Kimberly El, Brian Finan, Kyle W. Sloop, Mark A. Herman, David A. D’Alessio, Jonathan E. Campbell

​

Diabetes