Publications | Academic Lab | Campbell Lab | D'Alessio Lab | United States

Publications since 2015. DMPI-Endo members in Bold.

2025

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

Jonathan D Douros, Megan Capozzi, Aaron Novikoff, Jacek Mokrosinski, Barent DuBois, Joseph Stock, Rebecca Rohlfs, Mikayla Anderson, Dominika J Jedrzejcyk, Svend Poulsen, Erik Oude Blenke, Tomas Dago, Kasper Huus, Sune Kobberup, Marita Rivir, Joyce Sorrell, Stephanie Mowery, Daniel J Drucker, David A D'Alessio, Jonathan E Campbell, Timo D Muller, Diego Perez-Tilve, Patrick J Knerr, Brian Finan

bioRxiv

Glucose-dependent insulinotropic polypeptide (GIP)

Timo D Müller, Alice Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas Birkenfeld, Jonathan E Campbell, Matthew P Coghlan, David D’Alessio, Carolyn F Deacon, Stefano DelPrato, Jonathan D Douros, Daniel J Drucker, Natalie S Figueredo Burgos, Peter R Flatt, Brian Finan, Ruth E Gimeno, Fiona M Gribble, Matthew R Hayes, Christian Hölscher, Jens J Holst, Patrick J Knerr, Filip K Knop, Christine M Kusminski, Arkadiusz Liskiewicz, Guillaume Mabilleau, Stephanie A Mowery, Michael A Nauck, Aaron Novikoff, Frank Reimann, Anna G Roberts, Mette M Rosenkilde, Ricardo J Samms, Philip E Scherer, Randy J Seeley, Kyle W Sloop, Christian Wolfrum, Denise Wootten, Richard D DiMarchi, Matthias H Tschöp

Molecular Metabolism

Islet hormones at the intersection of glucose and amino acid metabolism

Phillip J White, Nicolai J Wewer Albrechtsen, Jonathan E Campbell

Nature Reviews Endocrinology

Development of a succinyl CoA: 3-ketoacid CoA transferase inhibitor with preference for peripheral versus central tissues that improves glycemia

Seyed Amirhossein Tabatabaei Dakhili, Kunyan Yang, Hamdah Al-Nebaihi, Amanda A Greenwell, Melinda Wuest, Jenilee Woodfield, Rabih Abou Farraj, Christina T Saed, Jordan SF Chan, Rakesh K Bhat, Indiresh A Mangra-Bala, Tanin Shafaati, Keshav Gopal, Farah Eaton, Sally R Ferrari, Cory S Wagg, Megan E Capozzi, Jonathan E Campbell, Michael Overduin, Carlos A Velazquez-Martinez, JN Mark Glover, Frank Wuest, Dion R Brocks, John R Ussher

iScience

2024

Activation of Gs K cells greatly improves obesity-and diabetes-related metabolic deficits signaling in mouse enteroendocrine

Antwi-Boasiako Oteng, Liu Liu, Yinghong Cui, Oksana Gavrilova, Huiyan Lu, Min Chen, Lee S Weinstein, Jonathan E Campbell, Jo E Lewis, Fiona M Gribble, Frank Reimann, Juergen Wess

Journal of Clinical Investigation

Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits

Antwi-Boasiako Oteng, Liu Liu, Yinghong Cui, Oksana Gavrilova, Huiyan Lu, Min Chen, Lee S Weinstein, Jonathan E Campbell, Jo E Lewis, Fiona M Gribble, Frank Reimann, Jürgen Wess

The Journal of Clinical Investigation

Characterization of genetic variants of GIPR reveals a contribution of B-arrestin to metabolic phenotypes

Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D’Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde

Nature Metabolism

Evaluating glucose-dependent insulinotropic polypeptide and glucagon as key regulators of insulin secretion in the pancreatic islet

Sophie L Lewandowski, Kimberley El, and Jonathan E Campbell

American Journal of Physiology-Endocrinology and Metabolism

Intra-islet Alpha-cell Gs signaling promotes glucagon release

Liu Liu, Kimberley El, Diptadip, Luiz F Barella, Yinghong Cui, Sarah M Gray, Carla Guedikian, Min Chen, Lee S Weinstein, Emily Knuth, Matthew J Merrins, Jeffery Roman, Klaus H Kaestner, Nicolai Doliba, Jonathan E Campbell, and Jurgen Wess

Nature Communications

High Doses of exogenous glucagon stimulate insulin secretion and reduce insulin clearance in healthy humans

Sarah M Gray, Elisha Goonatilleke, Michelle A Emrick, Jessica O Becker, Andrew N Hoofnagle, Darko Stefanovski, Wentao He, Guofang Zhang, Jenny Tong, Jonathan E Campbell, David D'Alessio

American Diabetes Association

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells, and delta cells

Ali H Shilled, Katrina Viloria, Johannes Broichhagen, Jonathan E Campbell, David J Hodson

Peptides

2023

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Kimberley El, Jonathan D Douros, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B Wainscott, Bin Yang, Alex Chen, Donald Wothe, Callum Coupland, Mattias H Tschöp, Brian Finan, David A D'Alessio, Kyle W Sloop, Timo D Muller, Jonathan E Campbell

Nature Metabolism

Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress

Evgenia Fadzeyeva, Cassandra A A Locatelli, Natasha A Trzaskalski, My-Anh Nguyen, Megan E Capozzi, Branka Vulesevic, Nadya M Morrow, Peyman Ghorbani, Antonio A Hanson, Ilka Lorenzen-Schmidt, Mary-Anne Doyle, Richard Seymour, Elodie M Varin, Morgan D Fullerton, Jonathan E Campbell, Erin E Mulvihill

JCI Insight

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O'Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann

JCI Insight

Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

Thao D V Le, Payam Fathi, Amanda B Watters, Blair J Ellis, Gai-Linn K Besing, Nadejda Bozadjieva-Kramer, Misty B Perez, Andrew I Sullivan, Jesse P Rose, Laurie L Baggio , Jacqueline Koehler, Jennifer L Brown, Michelle B Bales, Kaitlyn G Nwaba, Jonathan Campbell, Daniel J Drucker, Matthew J Potthoff, Randy J Seeley, Julio E Ayala

Molecular Metabolism

The ubiquitination status of the glucagon receptor determines signal bias

Suneet Kaur, Badr Sokrat, Megan E Capozzi, Kimberley El, Yushi Bai, Aeva Jazic, Bridgette Han, Kaavya Krishna Kumar, David A. D'Alessio, Jonathan E Campbell, Michel Bouvier, Sudha K Shenoy

Journal of Biological Chemistry

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity

Jack T Womble, Mark D Ihrie, Victoria L McQuade, Akhil Hegde, Matthew S McCravy, Sanat Phatak, Robert M Tighe, Loretta G Que, David A D'Alessio, Julia K L Walker, Jennifer L Ingram

Frontiers in Endocrinology

An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug

Imran Ozer, Anna Slezak, Parul Sirohi, Xinghai Li, Nikita Zakharov, Yunxin Yao, Jeffrey I Everitt, Ivan Spasojevic, Stephen L Craig, Joel H Collier, Jonathan E Campbell, David A. D'Alessio, Ashutosh Chilkoti

Biomaterials

2022

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Bin Yang, Vasily M Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J Knerr, David D'Alessio, Jonathan E Campbell, Jonathan D Douros, Brian Finan

Molecular Metabolism

The past, present, and future physiology and pharmacology of glucagon

Megan E Capozzi, David A D'Alessio, Jonathan E Campbell

Cell Metabolism

GLP-1 mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Baugé, Jonathan E Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M Hofmann, Patrick J Knerr, Konxhe Kulaj, Fanny Lalloyer, Heiko Lickert, Arek Liskiewicz, Daniela Liskiewicz, Gandhari Maity, Diego Perez-Tilve, Sneha Prakash, Miguel A Sanchez-Garrido, Qian Zhang, Bart Staels, Natalie Krahmer, Richard D DiMarchi, Matthias H Tschöp, Brian Finan, Timo D Müller

Nature Metabolism

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

Rashmi Chandra, Dipendra K Aryal, Jonathan D Douros, Rafiq Shahid, Supriya J Davis, Jonathan E Campbell, Olga Ilkayeya, Phillip J White, Ramona Rodriguez, Christopher B Newgard, William C Wetsel, Rodger A Liddle

Plos One

LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Shweta Urva, Tamer Coskun, Mei Teng Loh, Yu Du, Melissa K Thomas, Sirel Gurbuz, Axel Haupt, Charles T Benson, Martha Hernandez-Illas, David A D'Alessio, Zvonko Milicevic

Lancet

Risk factors for the development or progression of diabetic retinopathy in pregnancy: Meta-analysis and systematic review

Swara M Sarvepalli, Beth A Bailey, David A D'Alessio, Madleen Lemaitre, Anne Vambergue, Jay Rathinavelu, Majda Hadziahmetovic

Clinical and Experimental Ophthalmology

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction

Michael A Nauck, David A D'Alessio

Cardiovascular Diabetology

The GIPR is predominantly localized to non-adipocyte cell types within white adipose tissue.

Jonathan E. Campbell, Jacquline L. Beaudry, Berit Svendsen, Laurie L. Baggio, Andrew N. Gordon, John R. Ussher, Chi Kin Wong, Fiona M. Gribble, David A. D'Alessio, Frank Reimann, Daniel J. Drucker.

Diabetes

Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis

Sarah C Nyirjesy, Amy J Peleckis, Jack N Eiel, Kathryn Gallagher, Andriana Doliba, Abigail Tami, Anneliese J Flatt, Diva D De Leon, Denis Hadjiliadis, Saba Sheikh, Darko Stefanovski, Robert Gallop, David A D'Alessio, Ronald C Rubenstein, Andrea Kelly, Michael R Rickels

Cardiovascular Diabetology

Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetes

Darren K McGuire, David A D'Alessio, Stephen J Nicholls, Steven E Nissen, Jeffrey S Riesmeyer, Imre Pavo, Shanthi Sethuraman, Cory R Heilmann, John J Kaiser, Govinda J Weerakkody

Cardiovascular Diabetology

GLP-1 Receptor Blockade Reduces Stimulated Insulin Secretion in Fasted Subjects With Low Circulating GLP-1

Sarah M Gray, Andrew L Hoselton, Radha Krishna, Cris A Slentz, David A D'Alessio

Journal of Clinical Endocrinology and Metabolism

Slow and Steady Wins the Race: 25 Years Developing the GLP-1 Receptor as an Effective Target for Weight Loss

Nitya Kumar, David A D'Alessio

Journal of Clinical Endocrinology and Metabolism

A Lesson from 2020: Public Health Matters for Both COVID-19 and Diabetes

Matthew C Riddle, George Bakris, Lawrence Blonde, Andrew JM Boulton, David A D'Alessio, Linda A DiMeglio, Linda Gonder-Frerick, Korey K Hood, Frank B Hu, Steven E Kahn, Sanjay Paul, Lawrence A Leiter, Robert G Moses, Stephen S Rich, Julio Rosenstock, Judith Wylie-Rosett

Diabetes Care

2021

GIP mediates the incretin effect and glucose tolerance by dual actions on alpha cells and beta cells

Kimberley El, Sarah M. Gray, Megan E. Capozzi, Emily R. Knuth, Erli Jin, Berit Svendsen, Alexis Clifford, Jennifer L. Brown, Bryanna M. Chazotte, Kyle W. Sloop, Derek J. Nunez, Matthew J. Merrins, David A. D'Alessio, Jonathan E. Campbell

Science Advances

Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets

Schaffer AE, D'Alessio DA, Guyton JR.

J Clin Lipidol

Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes

Alonge KM, D'Alessio DA, Schwartz MW

Diabetologia

Mechanisms controlling pancreatic islet cell function in insulin secretion

Jonathan E. Campbell, Christopher B. Newgard

Nature Reviews Molecular Cell Biology

2020

Revisiting the complexity of GLP-1 action - from sites of synthesis to receptor activation

Brent A. McLean, Chi Kin Wong, Jonathan E. Campbell, David J. Hodson, Stefan Trapp, Daniel J. Drucker

Endocrine Reviews

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion

Guo-Fang Zhang, Mette V. Jensen, Sarah M. Gray, Kimberley El, You Wang, Danhong Lu, Thomas C. Becker, Jonathan E. Campbell, Christopher B. Newgard

Cell Metabolism

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms

Jonathan E. Campbell

Molecular Metabolism

Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway

Sophie L. Lewandowski, Rebecca L. Cardone, Hannah R. Foster, Thuong Ho, Evgeniy Potapenko, Chetan Poudel, Halena R. VanDeusen, Sophia M. Sdao, Tiago C. Alves, Xiaojian Zhao, Megan E. Capozzi, Arnaldo H. de Souza, Ishrat Jahan, Craig J. Thomas, Craig S. Nunemaker, Dawn B. Davis, Jonathan E. Campbell, Richard G. Kibbey, Matthew J. Merrins

Cell Metabolism

Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes

Kimberly M. Alonge, David A D'Alessio, Michael W. Schwartz

Diabetologia

Repositioning the alpha cell in postprandial metabolism

Kimberley El, Megan E. Capozzi, Jonathan E. Campbell

Endocrinology

Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice

Frank K. Huynh, Brett S. Peterson, Kristin A. Anderson, Zhihong Lin, Aeowynn J. Coakley, Fiara M.S. Llaguno, Thi-Tina N. Nguyen, Jonathan E. Campbell, Samuel B. Stephens, Christopher B. Newgard, Matthew D. Hirschey

American Journal of Physiology: Endocrinology and Metabolism

Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia

Caslin A. Gilroy, Megan E. Capozzi, Anastasia K. Varanko, Jenny Tong, David A. D'Alessio, Jonathan E. Campbell, Ashutosh Chilkoti

Science Advances

Could micro changes in beta-cells enable major changes in metabolism?

Megan E. Capozzi, Jonathan E. Campbell

EBioMedicine

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard, Jonathan D. Douros, Maria B.N. Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J.C. van der Velden, Cynthia Stutsman, Guemalli R. Cardona, Shweta Urva, Paul J. Emmerson, Jens J. Holst, David A. D'Alessio, Matthew P. Coghlan, Mette M. Rosenkilde, Jonathan E. Campbell, Kyle W. Sloop

JCI Insight

Preliminary evidence of effects of potassium chloride on a metabolic path to diabetes and cardiovascular disease

Ranee Chatterjee, Clementine A. Davenport, Lydia Kwee, David D'Alessio, Laura P. Svetkey, Pao-Hwa Lin, Cris A. Slentz, Olga Ilkayeva, Johanna Johnson, David Edelman, Svati H Shah

Metabolomics

Thermic effect of food and resting energy expenditure after sleeve gastrectomy for weight loss in adolescent females

Bonnie Brehm, Suzanne Summer, Todd Jenkins, David D'Alessio, Thomas Inge

Surgery for Obesity and Related Disorders

Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study

Jeremy H. Pettus, David A D'Alessio, Juan P. Frias, Eric G. Vajda, James D. Pipkin, Julio Rosenstock, Gretchen Williamson, Miriam A. Zangmeister, Lin Zhi, Keith B. Marschke

Diabetes Care

Discordance between GLP-1R gene and protein expression in mouse pancreatic islets cells

Sarah M. Gray, Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, Peter Ravn, Kyle W. Sloop, Jenny Tong, Jesper Gromada, Jonathan E. Campbell, David A. D'Alessio

Journal of Biological Chemistry

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

Rami Al Batran, Keshav Goal, Megan E. Capozzi, Jadin J. Chahade, Bruno Saleme, S. Amirhossein Tabatabaei-Dakhili, Amada A. Greenwell, Jingjing Nui, Malak Almutairi, Nikole J. Myme, Grant Masson, Ryekjang Kim, Carlos A. Velazquez-Martinez, Celine Agues, Peter A. Crawford, Gopinath Sutendra, Jonathan E. Campbell, Jason R.B. Dyck, John R. Ussher.

Cell Metabolism

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, Kimberly El, Brian Finan, Kyle W. Sloop, Mark A. Herman, David A. D’Alessio, Jonathan E. Campbell

Diabetes

2019

2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

John B Buse, Deborah J Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A D'Alessio, Melanie J Davies

Diabetes Care

2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

John B Buse, Deborah J Wexler, Apostolos Tsapas, Peter Rossing, Geltrude Mingrone, Chantal Mathieu, David A D'Alessio, Melanie J Davies

Diabetologia

Pharmacological Antagonism of the Incretin System Protects Against Diet-induced Obesity.

Berit Svendsen, Megan E Capozzi, Jingjing Nui, Sarah A Hannou, Brian Finan, Jacqueline Naylor, Peter Ravn, David A D’Alessio, Jonathan E Campbell.

Molecular Metabolism

Rapid hepatic metabolism blunts the endocrine actions of portally infused GLP-1 in male rats.

Benedikt A Aulinger, Marta Perabo, Randy J Seeley, Klaus G Parhofer, David A D'Alessio

American Journal of Physiology Endocrinology and Metabolism

The effects of preioperative dexamethasone on glycemic control and postoperative outcomes.

Rebecca A Herbst, Onala T Telford, John Hunting, W Michael Bullock, Erin Manning, Beatrics D Hong, David A D'Alessio, Tracy L Setji

Endocrine Practice

L-citrulline supplementation improvew glucose and exercise tolerance in obese male mice

Amina Eshreif, Rami Al Batran, K Lockhart Jamieson, Ahmed M Darwesh, Keshav Gopal, Amanda A Greenwell, Igor Zlobine, Hanin Aburasayn, Farah Eaton, Erin E Mulvihill, Jonathan E Campbell, John M Seubert, John R Ussher

Experimental Physiology

The role of GIP in α-cells and glucagon secretion

Kimberley El, Jonathan E Campbell

Peptides

Physiological roles of the GIP receptor in murine brown adipose tissue

Jacqueline L Beaudry, Kiran D Kaur, Elodie M Varin, Laurie L Baggio, Xiemin Cao, Erin E Mulvihill, Holly E Bates, Jonathan E Campbell, Daniel J Drucker

Molecular Metabolism

The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control

Jonathan D Douros, Jenny Tony, David A D'Alessio

Endocrine Reviews

Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control

Jonathan D Douros, Jingjing Niu, Sophia Sdao, Trillian Gregg, Matthew J Merrins, Jonathan Campbell, Jenny Tong, David D'Alessio

Molecular Metabolism

The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice.

Chelsea R. Hutch, Karen Roelofs, April Haller, Joyce Sorrell, Kyle Leix, David A. D'Alessio, Robert Augustin, Randy J. Seeley, Thomas Klein, Darleen A. Sandoval

Diabetologia

Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery

Marzieh Salehi, Amalia Gastaldelli, David A D'Alessio

Gut

One small step for mice, one giant leap for GWAS?

Mark A Herman, Jonathan E Campbell, David A D’Alessio

Journal of Clinical Investigation

Glucagon lowers glycemia when β cells are active

Megan E Capozzi, Jacob B Wait, Andrew N Gordon Jepchumba Koech, Reilly W Coch, Berit Svendsen, Brian Finan, David A D’Alessio, Jonathan E Campbell

JCI Insight

Intra-Islet Ghrelin Signaling does not Regulate Insulin Secretion from Adult Mice

Sarah M Gray, Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E Campbell, David A D’Alessio, Jenny Tong

Diabetes

Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes

Brian Finan, Megan E Capozzi, Jonathan E Campbell

Diabetes

Role of vagal activation in postprandial glucose metabolism after gastric bypass in individuals with and without hypoglycemia

Marzieh Salehi, Amalia Gastaldelli, David A D'Alessio

Diabetes, Obesity, and Metabolism

Reg3 Proteins as Gut Hormones? Don’t Be Hasty

Jonathan D Douros, Jonathan E Campbell

Endocrinology

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

Jacqueline L Beaudry, Kiran Deep Kaur, Elodie M Varin, Laurie L Baggio, Xiemin Cao, Erin E Mulvihill, Jennifer H Stern, Jonathan E Campbell, Phillip E Scherer, Daniel J Drucker

Molecular Metabolism

Sleeve gastrectomy rapidly enhances islet function independently of body weight

Jonathan D Douros, Jingjing Niu, Sophia Sdao, Trillian Gregg, Kelsey Fisher-Wellman, Manish Bharadwaj, Anthony Molina, Ramamani Arumugam, MacKenzie Martin, Enrico Petretto, Matthew J Merrins, Mark A Herman, Jenny Tong, Jonathan E Campbell, David A D’Alessio

JCI Insight

Beta Cell tone is defined by proglucagon peptides through cAMP signaling

Megan E Capozzi, Berit Svendsen, Sara E Encisco, Sophie L Lewandowski, Mackenzie D Martin, Haopeng Lin, Justin L Jaffe, Reilly W Coch, Jonathan M Haldeman, Patrick E MacDonald, Matthew J Merrins, David A D’Alessio, Jonathan E Campbell

JCI Insight

Circulating levels of soluble dipeptidyl peptidase-4 are dissociated from inflammation and induced by enzymatic dpp4 inhibition

Elodie M Varin, Erin E Mulvihill, Jacqueline L Beaudry, Gemma Pujadas, Shai Fuchs, Jean-François Tanti, Sofia Fazio, Kirandeep Kaur, Xiemin Cao, Laurie L Baggio, Dianne Matthews, Jonathan E Campbell, Daniel J Drucker

Cell Metabolism

2018

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Melanie J Davies, David A D'Alessio, Judith Fradkin, Walter N Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J Wexler, John B Buse

Diabetologia

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Melanie J Davies, David A D'Alessio, Judith Fradkin, Walter N Kernan, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Apostolos Tsapas, Deborah J Wexler, John B Buse

Diabetes

Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet

Rami Al Batran, Keshav Gopal, Mackenzie D Martin, Kim L Ho, Malak Almutairi, Hanin Aburasayn, Farah Eaton, Jonathan E Campbell, John R Ussher

Diabetologia

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Tamer Coskun, Kyle W Sloop, Corina Loghin, Jorge Alsina-Fernandex, Shweta Urva, Krister B Bokvist, Xuewei Cui, Daniel A Briere, Over Cabrera, William C Roell, Uma Juchibholta, Julie S Moyers, Charles T Benson, Ruth E Gimeno, David A D'Alessio, Axel Haupt

Molecular Metabolism

Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans

Laura C Page, Amalia Gastaldelli, Sarah M Gray, David A D'Alessio, Jenny Tong

Diabetes

Enhanced glucose control following vertical sleeve gastrectomy does not require a β-cell glucagon-like peptide 1 receptor

Jonathan D Douros, Alfor G Lewis, Eric P Smith, JingJing Niu, Megan Capozzi, April Wittmann, Jonathan Campbell, Jenny Tong, Constance Wagner, Parinaz Mahbod, Randy Seeley, David A D’Alessio

Diabetes

Can we RISE to the Challenge of Youth-Onset Type 2 Diabetes?

John B Buse, David A D'Alessio, Matthew C Riddell

Diabetes Care

Remodeling of the acetylproteome by SIRT3 manipulation fails to affect insulin secretion or β cell metabolism in the absence of overnutrition

Brett S Peterson, Jonathan E Campbell, Olga Ilkayeva, Paul A Grimsrud, Matthew D Hirschey, Christopher B Newgard

Cell Reports

Targeting the incretin/glucagon system with triagonists to treat diabetes

Megan E Capozzi, Richard D DiMarchi, Matthias H Tschöp, Brian Finan, Jonathan E Campbell

Endocrine Reviews

Inactivation of the glucose-dependent insulinotropic polypeptide receptor improves outcomes following experimental myocardial infarction

John R Ussher, Jonathan E Campbell, Erin E Mulvihill, Laurie L Baggio, Holly E Bates, Brent A McLean, Keshav Gopal, Megan Capozzi, Bernardo Yusta, Xiemin Cao, Safina Ali, Minsuk Kim, M Golam Kabir, Yutaka Seino, Jinya Suzuki, Daniel J Drucker

Cell Metabolism

2017

Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes

Matthew J Crowley, John W Williams, Andrzej S Kosinski, David A D'Alessio, John B Buse

Diabetes Care

β-cell inactivation of GPR119 unmasks incretin dependence of GPR119-mediated glucoregulation

Brandon L Panaro, Grace B Flock, Jonathan E Campbell, Jacqueline L Beaudry, Xiemin Cao, Daniel J Drucker

Diabetes

SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion

Kristin A Anderson, Frank K Huynh, Kelsey Fisher-Wellman, J Darren Stuart, Brett S Peterson, Jonathan D Douros, Gregory R Wagner, J Will Thompson, Andreas S Madsen, Michelle F Green, R Michael Sivley, Olga R Ilkayeva, Robert D Stevens, Donald S Backos, John A Capra, Christian A Olsen, Jonathan E Campbell, Deborah M Muoio, Paul A Grimsrud, Matthew D Hirschey

Cell Metabolism

DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain

Jonathan E Campbell, David A D’Alessio

Journal of Clinical Investigation

Disruption of Glucagon-LIke Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress

Sriparna Ghosal, Amy EB Packard, Parinaz Mahbod, Jessica M McKlveen, Randy J Seeley, Brent Myers, Yvonne Ulrich-Lai, Eric P Smith, David A D'Alessio, James P Herman

Journal of Neuroscience

Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis

Erin E Mulvihill, Elodie M Varin, Bojana Gladanac, Jonathan E Campbell, John R Ussher, Laurie L Baggio, Bernardo Yusta, Jennifer Ayala, Melissa A Burmeister, Dianne Matthews, KW Annie Bang, Julio E Ayala, Daniel J Drucker

Cell Metabolism

2016

Incretin-based therapies for the failing heart

John R Ussher, Jonathan E Campbell

Cardiovascular Endocrinology & Metabolism

Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor - Maybe

Marzieh Salehi, David A D'Alessio

Surgery for Obesity and Related Disease

Inhibition of dipeptidyl peptidase-4 impairs ventricular function and promotes cardiac fibrosis in high fat–fed diabetic mice

Erin E Mulvihill, Elodie M Varin, John R Ussher, Jonathan E Campbell, KW Annie Bang, Tahmid Abdullah, Laurie L Baggio, Daniel J Drucker

Diabetes

Bariatric/metabolic surgery for diabetes: Incorporating a powerful treatment into standard care

Bruce M Wolfe, David A D'Alessio

Obesity

TCF1 links GIPR signaling to the control of beta cell function and survival

Jonathan E Campbell, John R Ussher, Erin E Mulvihill, Jelena Kolic, Laurie L Baggio, Xiemen Cao, Yu Liu, Benjamin J Lamont, Tsukasa Morii, Catherine J Streutker, Natalia Tamarina, Louis H Philipson, Jeffrey L Wrana, Patrick E MacDonald, Daniel J Drucker

Nature Medicine

The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?

Benedikt A Aulinger, Torsten P Vahl, Ron L Prigeon, David A D'Alessio, Deborah A Elder

American Journal of Physiology Endocrinology and Metabolism

2015

Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus

Roger D Gibb, Johnson W McRorie, Darrel A Russell, Vic Hasselblad, David A D'Alessio

Amercial Journal of Clincial Nutrition

Insulin Sensitivity and Beta-cell Function Improve after Gastric Bypass in Severely Obese Adolescents

Thomas H Inge, Ronald L Prigeon, Deborah A Elder, Todd M Jenkins, Robert M Cohen, Stavra A Xanthakos, Stephen C Benoit, Lawrence M Dolan, Stephen R Daniels, David A D'Alessio

Journal of Pediatrics

Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone

Daniel Oropeza, Nathalie Jouvet, Lionel Budry, Jonathan E Campbell, Khalil Bouyakdan, Julie Lacombe, Gabrielle Perron, Valerie Bergeron, Joshua C Neuman, Harpreet K Brar, Rachel J Fenske, Clemence Meunier, Sarah Sczelecki, Michelle E Kimple, Daniel J Drucker, Robert A Screaton, Vincent Poitout, Mathieu Ferron, Thierry Alquier, Jennifer L Estall

Diabetes

Islet α cells and glucagon—critical regulators of energy homeostasis

Jonathan E Campbell, Daniel J Drucker

Nature Reviews Endocrinology

Insulin Determir is Transported From Blood to Celebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin

Denovan P Begg, Aaron A May, Joram D Mul, Min Liu, David A D'Alessio, Randy J Seeley, Stephen C Woods

Diabetes

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Jacqueline A Koehler, Laurie L Baggio, Xiemin Cao, Tahmid Abdulla, Jonathan E Campbell, Thomas Secher, Jacob Jelsing, Brett Larsen, Daniel J Drucker

Diabetes

Diet-induced obese mice retain endogenous leptin action

Nickki Ottaway, Parinaz Mahbod, Belen Rivero, Lee Ann Norman, Arieh Gertler, David A D'Alessio, Diego Perez-Tilve

Cell Metabolism

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan, Bin Yang, Nickki Ottaway, David L Smiley, Tao Ma, Christoffer Clemmensen, Joe Chabenne, Lianshan Zhang, Kirk M Habegger, Katrin Fischer, Jonathan E Campbell, Darleen Sandoval, Randy J Seeley, Konrad Bleicher, Sabine Uhles, William Riboulet, Jürgen Funk, Cornelia Hertel, Sara Belli, Elena Sebokova, Karin Conde-Knape, Anish Konkar, Daniel J Drucker, Vasily Gelfanov, Paul T Pfluger, Timo D Müller, Diego Perez-Tilve, Richard D DiMarchi, Matthias H Tschöp

Nature Medicine

This information is intended to be a resource for members of the DMPI Endocrinology group